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DiscussionPolycythemia Vera and Nutritional Ketosis
Blood Cancers & Disorders | Last Active: 3 days ago | Replies (64)Comment receiving replies
Replies to "Hello, does anyone know if DDR (DNA Damage Repair) can take place on the JAK2 V617F..."
They say it's permanent, but then they can't tell you how it happened in the first place! My theory is that there is a DNA switch and it changed, why couldn't it change back? The problem is figuring out how to do it.
Hi @tennis7777, welcome to Connect. I’m not a medical professional but from my experience of having 3 acquired genetic mutations which caused my leukemia, once a gene has mutated they don’t reverse on their own.
There are medications/treatments which can help slow the proliferation of the damaged cells but they don’t reverse the mutation. Stem cell transplants and Car T therapies can be potential cures for patients.
Some mutations may be corrected through Genome editing, as indicated in this article:
>Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247858#:~:text=Here%20we%20develop%20“scarless”%20Cas9-based%20reagents%20to%20create,%28HSPCs%29%2C%20and%20immunophenotypic%20long-term%20hematopoietic%20stem%20cells%20%28LT-HSCs%29.
Have you been diagnosed with a blood condition because of a JAK2 V617F mutation?