I had two shots on 12/26 and on 2/1 I declined the second. I believe the full dose is too much for some of us: it is based on a 150 pound person. Evenity inhibits sclerostin and sclerostin is present throughout the body. Studies found that those with osteoarthritis and rheumatoid arthritis have low levels of sclerostin. It is also important in cartilage repair. Dr. McCormick told me that 40% of his patients experience joint pain.

Even with a half dose, after two treatments, I am having joint and bone pain and burning pins and needles all over. My upper chest hurts: ribs? muscle?

Evenity's action peaks at days 2-7 with the average 5 days. Its half life is 12.8 days after 3 sets of injections, a long half life (though nowhere near that of Reclast).

I have reduced doses of every med I take, including Tymlos and future Reclast. I am resisting the standardized dose of Evenity but technically the treatment should be 3mg/kg and one shot is 2mg/kg. That means 10% effectiveness versus 16% for the full dose. For me, the full dose would be 1 1/3 shots! I wish I could give it to myself!

Is anyone else having complicated, strange dreams? This effect on my brain is concerning more than anything else.

Most people do fine with full dose and I am exceptionally sensitive to all meds, and have several health conditions including lupus. I don't want to discourage others from trying Evenity or any other medication if it is needed. I have suffered fractures and side effects that are tolerable are not an obstacle for me, only side effects that are absolutely not tolerable. Fractures are disabling and painful and I will suffer a lot to avoid more.