I was diagnosed with breast cancer 2/23/22 at the age of 47 and I truly wish that both my oncologist and gynecologist told me to get a transvaginal ultrasound prior to going on Tamoxifen so I would have had a baseline to compare. I have been on 20mg of Tamoxifen for 1.5 years along with monthly Zoladex injections (@ a year). I am chemically induced into having no periods, but I am nowhere near going into menopause based upon recent bloodwork. My uterine lining continues to thicken yet no shedding. My annual gyno check up in late fall revealed a thickened endometrial lining and polyp. I started bleeding and had to have a D&C and polypectomy right before Christmas.

I too have gone back and forth about getting a hysterectomy and oophorectomy as my uterine lining thickening will continue to pose as an issue until I have reached menopause. Everyone reacts differently to Tamoxifen; my body just has a lot of issues with it in addition to the uterine side effects. Tamoxifen has estrogenic effects on the uterus and anti-estrogenic effects in the rest of the body. It is very confusing and I had to find out about it reading medical journals and recent NIH studies. Have frank conversations with your gynecologist and oncologist and do your own research to come to a fully informed decision for what is best for you and your body. Best wishes and hang in there!