Your story mirrors mine. I went through the exact situation for a long time. Many Blood transfusions. I was taking both Aranesp and Reblozyl injections to boost my Red cell count. When I started taking VONJO, my spleen shrank very quickly and that alone helped me to feel better. The they started me on Dacogen infusions. It made me feel bad, but over time it killed a lot of cancer cells. When they took me off of it, things jumped up higher than they had been in 10 years! I've been riding that high for close to a year now. I'm sure it is slowly starting back down, but it is still FAR better than when I started. If things get back to the low end eventually, I may have to restart the Dacogen, or move on to a new drug. Good luck with your treatments and don't let fear get you down. If you are of such a persuasion, then believe.