So glad people are posting abt leg weakness on Eliquis. This can explain mine. I am 74 have been kn eliquis for 8 years for paroxysmal afib. Two years ago i developed sudden weakness in lower extremities. Up til that point I had been participating in HIIT twice a week plus other aerobic activities when suddenly i couldn’t lift the ropes ( exercise equipment). Now again having very weak legs even though I am working out and strength training.