Any suggestions on what time of day is best for taking Hydroxyurea?

Very interesting, I get short of breath alot

I take my HU at 7PM(after dinner) every night.. That has worked out well for me…

I take mine before I go to bed. Works for me

I found it works best for me to take it in the evening as well. I figured if it’s going to make me lightheaded and tired it might as well be before I go to bed.😊

Taking right before bedtime gave me bad dreams, so taking sometime after dinner works best for me. (Taking in the morning made me drowsy.)

My hematologist recommended a half hour before or after eating. I was also told to drink a full glass of water with it. It is also recommended to have 64 ounces of fluids daily to guard against the toxicity of Hydroxyurea.

Strange. I take Hydro 500 mg twice a day and have never felt anything different. I was never told to drink lots of water or take at any time that that would be best. I just take it with my morning supplement pills and before bed again with my supplements. But, two years ago my PLT count was 2057 and I was very fatigued, so I started with Hydroxyurea and in Aug 2024 my PLT was down to 671. Not where it's suppose to be but a great improvement!

I've been taking my daily 600 mgs(Droxia) in the evening, along with my other meds, for the past 6yrs. It has worked for me--lowered my platelets to normal range, while keeping other counts normal, and preventing splenomegaly.

I also take my HU at 730 every night, about 1 1/2 hours after dinner, with lots of water and sometimes a few spoonfuls of cottage cheese. It works for me. My dr told me to take 2 caps HU at same time every day, so I have my devices set to remind me

I was told to take my hydrea with plenty of water. If I do that at night, I wake up more often for the bathroom (sometimes happens when we are older) so I switched to morning with my breakfast. Have had no problems inthe last three years.