I too have been plagued by the nose sore, just in one nostril. I ended up with a MRSA infection after endometrial cancer surgery and since, the sore lives on. I get some relief by alternating Carmex and an antibiotic OTC ointment, it seems if I can keep it somewhat moisturized, it feels a little better. I understand what others say about the bleed---if it does, it is fast & profuse, literally running out of my nose like a faucet. If I do remove the scab, it must directly correlate to my sinuses because my teeth hurt immediately. I also have rheumatoid arthritis (JRA since I was 6), so-- maybe someone can make the correlation between autoimmune diseases and this annoyance!