I have been on low dose aspirin and hydroxyurea for about 3 months. I have an unrelated surgery complication and am bedridden and so I am not in the sun. At the beginning my stools were very soft and sometimes still are. I felt some fatigue, but minor. My doc has increased my dose along the way, but I have adjusted well. I excercise as best I can with my surgery complication and feel great. I eat a very healthy Mediterranean diet. My platelet count is much lower than yours. I hate taking medications but I know the hydroxyurea is keeping my platelet count at a safer number so I will continue to take it and am grateful to have it. All the best!