I have been taking 500 mg. per day of hydroxyurea since August of 2023. Daily leg pain is caused by hydroxyurea for me. Also, any former injury I have had in the past is attacked by the hydroxyurea and causes pain. The knee I injured in high school gymnastics in 1969 never had an issue with pain and instability until hydroxyurea and the knee has become more unstable and painful. 40 years ago I had Bell's Palsy when pregnant with our son, and I never had pain in the eye that is located on the side of my face where the Bell's Palsy occured. A few times a month I get a stabbing pain in the Bell's Palsy eye and that never happened unitl I was prescribed hydroxyurea for essential thrombocytosis. Weird as can be.