It does sound a bit of overkill starting on 4 drugs. I started on Revlimid and dexamethasone. After a year I had daratumumab added. I was on this for 4years. That regimen started to not work and I opted for a stem cell transplant. I am currently only on Pomalyst maintenance. I am mrd negative. At one year post transplant (March) I will have another bone marrow biopsy and if I am still mrd negative I can stop the Pomalyst.

@ginorio You might want to ask your oncologist the reason for being so aggressive if your diagnosis is smoldering myeloma at this point.

Like you, I am also a kidney disease patient. And that should play a factor in how your situation is handled. In my case, my oncologist and nephrologist are in contact with each other. My myeloma is not being aggressively treated because the medications would really subject my CKD to negative responses. I am on dialysis for my kidneys, and the side effects of strenuous myeloma treatment would be a real issue for me, and detrimental to my overall health. This was discussed with my oncologist, nephrologist and me, all of us coming to the same agreement/conclusion. I am on Revlimid and dexamethasone.

Advocate for yourself. I'm here if you have more questions.
Ginger