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Cambridge Study: Unintended Immune Response with COVID Vaccine
Excerpts from Yahoo News / The Telegraph article on a Cambridge study: One in four who had Pfizer Covid jabs experienced unintended immune response
But in 2023, the Nobel Prize for Medicine went to the pair of scientists who had spent years working to fix the problem. It was done by taking one of the RNA bases, uridine, and swapping in a very similar synthetic alternative.
This breakthrough allowed scientists to create proteins in the body without the immune system attacking the jab.
It allows for quick and precise vaccines that are highly effective and was the backbone of the Covid vaccine response.
Not a perfect fit
It was thought the minor tweak to uridine caused no problems in cells, but a team of researchers at the University of Cambridge’s Medical Research Council (MRC) Toxicology Unit have now found when this partially synthetic code is read, the protein-making machine in the body sometimes struggles with the uridine analogues.
Because it is not a perfect fit for what is expected, there can be a momentary pause which causes the process to stutter and a letter in the code can get skipped, much like a bike slipping a gear.
This process, called frameshifting, throws out the way the code is interpreted as it relies on groups of three bases, known as codons, being read in the right order.
This issue, caused by the jab’s code, throws the process completely out of sync and the entire subsequent code becomes garbled.
In the case of the Covid jabs, the end result is a nonsensical and harmless protein, the team found, which the body attacks and leads to an immune system flare-up. The new study, published in Nature, found this occurred in around 25-30 per cent of people.
https://news.yahoo.com/more-one-four-had-mrna-171724613.html
*Moderators Note*
Data from this article is from a Cambridge Study which found no ill-effects from a small sample survey of patients: https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses
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Hello @searcher1. The study that The Telegraph referenced from the University of Cambridge (https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses) states:
"In collaboration with researchers at the Universities of Kent, Oxford and Liverpool, the MRC Toxicology Unit team tested for evidence of the production of ‘off-target’ proteins in people who received the mRNA Pfizer vaccine against COVID-19. They found an unintended immune response occurred in one third of the 21 patients in the study who were vaccinated – but with no ill-effects, in keeping with the extensive safety data available on these COVID-19 vaccines.
The team then redesigned mRNA sequences to avoid these ‘off-target’ effects, by correcting the error-prone genetic sequences in the synthetic mRNA. This produced the intended protein. Such design modifications can easily be applied to future mRNA vaccines to produce their desired effects while preventing hazardous and unintended immune responses."
Unfortunately, the data from this study was misconstrued and circulated widely on social media where some publications misrepresented the data.
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5 ReactionsIf sources are unreliable, I will no longer post on the blog.
Hey Justin,
Seems like you understand this stuff. Can you restate it really simply? Or, maybe, just state the implications, if any, for future vaccines?
Thanks a bunch!
Anne
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