@wisco50 Thanks for the reply. All the information out there helps. After I got down to Cymbalta 20mg and then weaned off completely in about a week, I’ve gone into a rather deep depression that I can’t attribute to anything but the cessation of Cymbalta. After a week on Wellbutrin 150 I may be feeling just the tiniest improvement. I’ve always carried a mild depression but this one was worse. The only negative I have experienced with Wellbutrin is I sleep from about 11pm to 10am! Then when I get up I have to hold the walls for a bit to keep upright. This should be temporary. BTW, I didn’t suffer the difficult weaning process with Cymbalta that a lot of people experience, except I immediately started having a LOT more pain when I got to 20mg so went to 30mg for awhile. But my weight kept ballooning and that motivated me to get off completely and try to control my pain in other ways. I dropped my Lyrica at the same time. Sure enough, my weight started dropping after I quit. I have a Spinal Cord Stimulator and turned it off too. But couldn’t take the pain that returned so turned on the SCS in a day. It doesn’t cure all my pain but definitely offers a good layer of pain reduction. I just have to figure out a med that can accompany this and bring my tailbone and left lower back pain into a manageable level. I started back on Lyrica last night but in a lower dose. Hope all this is not TMI.