Gastroenterology & GI Surgery

Welcome to the Mayo Clinic Gastroenterology & GI Surgery Page! With one of the largest group of digestive disease specialists in the world, Mayo Clinic has been recognized as the nation's best Gastroenterology & GI Surgery hospital by U.S. News & World Report.
Follow the page to read shared experiences, learn about clinical trials and up-to-date research, and find resources for all your gastroenterology needs. Our goal is to connect you to others, and become informed decision makers; so post a comment, share your story, own your health.

PUBLIC PAGE
Mon, May 15, 2017 11:27am

Genetics and Celiac Disease - Who is at Risk?

By Kanaaz Pereira, Connect Moderator, @kanaazpereira

Genetic predisposition plays a key role in celiac disease (CD), and that could mean as many as a third of the population  are genetically at risk! The great majority however, never get celiac disease. Dr. Joseph Murray explains the results of a recent study that delves deeper into finding the various genomic factors responsible for CD predisposition. The published study can be found in the journal PLOS One.

According to the study: "Although the HLA genotypes are necessary for celiac disease, they are common and insufficient to cause disease, and each individual celiac patient will have a genetic etiology that includes non-HLA disease alleles."  Considerable progress has been made in identifying these genes, but there are many gaps that need to be filled to fully understand the genetic architecture of celiac disease.

Read the full study online here.

For more information about celiac disease, visit mayoclinic.org/celiac disease.

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

Please login or register to post a reply.

Invite Others

Send an email to invite people you know to join the Gastroenterology & GI Surgery page.

We'll include this text in the user's invitation.