Gastroenterology & GI Surgery

Welcome to the Mayo Clinic Gastroenterology & GI Surgery Page! With one of the largest group of digestive disease specialists in the world, Mayo Clinic has been recognized as the nation's best Gastroenterology & GI Surgery hospital by U.S. News & World Report. Follow the page to learn about clinical trials and up-to-date research, and find resources for all your gastroenterology needs. Our goal is to connect you to others, and become informed decision makers; so post a comment, share your story, own your health.

Mar 10, 2017

Vedolizumab Safe for Inflammatory Bowel Disease

By Kanaaz Pereira, Connect Moderator, @kanaazpereira

Vedolizumab (proposed trade name Entyvio), was developed as a treatment for patients with moderate to severe ulcerative colitis (UC) or Crohn's disease (CD), who have failed at least one conventional therapy, including tumor necrosis factor (TNF) antagonists. Dr. Edward Loftus, M.D., reviews a recent study published in the journal Gut, in which researchers reported on the safety profile of vedolizumab.

What is already known on this subject?

  • Vedolizumab is a monoclonal antibody that selectively prevents the infiltration of leucocytes into the gastrointestinal submucosa.
  • The efficacy and safety of vedolizumab in adults with IBD have been demonstrated in several clinical trials with follow-up to 1 year.

What are the new findings?

  • Treatment with vedolizumab for up to 5 years in a population of over 2800 patients demonstrated a favourable safety profile.
  • Vedolizumab is not associated with an increased risk of serious or opportunistic infections, and the rate of malignancy (0.1/100 person-years) is consistent with that observed in patients with IBD normally.

Although a favourable benefit-risk profile makes vedolizumab a useful option for the long-term treatment of IBD, researchers still need to better understand and observe how its safety profile evolves over time.

Read the full study online here.

For more information about IBD, visit

Dr. Loftus is a gastroenterologist at Mayo Clinic.

Please login or register to post a reply.

Invite Others

Send an email to invite people you know to join the Gastroenterology & GI Surgery page.

Please login or register to send an invite.