My husband has also been diagnosed with Myelofibrosis, started on Jakifi a week ago, no side effects yet, hopefully none will show up. Spleen enlarged, no appetite, lots of weight loss, fatigue and being tired all the time. Would like to get any information from someone else who has this rare bone marrow disease. Also life expectancy. He is 83 and has been told 4 t0 5 years depending on certain criteria. His age is against him for a bone marrow transplant or surgery to remove his spleen. Any input will be greatly appreciated from anyone.