Hello, my name is Sheri and I have ulcerative colitis and RA. I am on many anti-inflammatory medications for both conditions. Sulfasalazine, Methotrexate injections weekly, and Cimzia injections. When the RA flares became acute (occurring every 3-4 weeks) the Methotrexate was added to the already prescribed Sulfasalazine 4 tablets 2x daily. The add of Methotrexate reduced the frequency of flares for me to one every 5 weeks and after a year of trying the two meds the Cimzia was added. I have now been able to reduce the sulfasalazine to 2 tablets 2x daily, continue the Methotrexate injections weekly and the Cimzia – 2 injections every 28 days. I am thrilled to report I too was very timid about giving myself shots, but do the weekly Methotrexate without thinking twice about it. I've found icing the injection location prior to injecting makes it pain free for me. The Cimzia shots are another story and I do numb with ice prior to injecting but need to have my DH do those for me every 28 days. For me it's all about tradeoff's and well worth the shots. I am approaching 2 years without a significant RA flare – Cimzia was life changing for me in a great way. I hope you are able to find relief in your journey. I have found some FB groups for Methotrexate and Cimzia to be helpful, there maybe a group for the biologic they are recommending for you. I wish you hope and healing in your search for relief.