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Jan 8, 2018 · Meet Dr. Dennis Wigle in Chest Surgery

Dr. Dennis Wigle 1

Meet Dennis Wigle, M.D., Ph.D a thoracic surgeon at the Rochester, Minnesota Campus. Dr. Wigle shares that Mayo Clinic is like no other place in the world wrapping together the best clinic trial based research, the best basic science into the overall goal of patient care.

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Dec 18, 2017 · The ALCHEMIST Lung Cancer Trial in Chest Surgery

Dr. Dennis WigleMayo Clinic is currently enrolling patients for the ALCHEMIST Lung Cancer trial. We encourage you to speak to your surgeon about this very important lung cancer trial. For those patients undergoing early stage lung cancer surgery at Mayo Clinic, a study coordinator will review your case and reach out to you if your meet the eligibility criteria.

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Mar 30, 2017 · Renaissance in Medicine in Chest Surgery

Renaissance in Medicine

Renaissance means rebirth or regeneration. Every few generations medicine takes a major turn. We’re at one of those junctures now with regenerative medicine — where healing is triggered from within the human body. It’s bringing a whole new universe to how physicians provide care.

Full article published March 2017, Discovery’s Edge

More than half of the clinical trials that fall under the Center for Regenerative Medicine’s purview involve the use of stem cell-based therapies of one kind or another. Dennis Wigle, M.D., Ph.D., a thoracic surgeon at Mayo Clinic in Minnesota, is performing one such trial aimed at regenerating lung tissue. He and his team are working to develop new therapies for people with a wide range of lung diseases, including chronic obstructive pulmonary disease and cystic fibrosis. First they collect cells from the skin of people with various end-stage lung diseases and then they turn them into patient-specific stem cells, and grow them into lung cells with a view towards delivering them back to the patient.

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Oct 11, 2016 · Lung Regeneration in Chest Surgery

Wigle in the LabThere are hundreds of thousands of patients in the United States with end stage lung disease. Many of them are not candidates for lung transplantation or other therapies. Learn now lung regeneration, through the use of existing cells to build an artificial lung, is building a brighter future for patients with few treatment options.

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Explore Mayo’s Center for Regenerative Medicine



Jul 5, 2016 · Regenerative Medicine Offering New Treatment for Bronchopleural Fistulas in Chest Surgery

Scientist working with a microscope

When current treatment isn’t enough, patients at Mayo Clinic often are among the first to benefit from innovative therapies, new techniques and technologies. For the first time in human application, Mayo Clinic researchers successfully closed an open wound on the upper chest caused by postoperative complications of lung removal. The findings appear in the journal Stem Cells Translational Medicine.

Full article at Mayo Clinic News Network 

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Nov 17, 2014 · Chromosomal Rearrangements Help Distinguish Between Independent Primary Tumors and Metastasis in Chest Surgery

A diagnostic test based on chromosomal rearrangements can trace the lineage of lung cancer to determine whether two separate lung cancers in the same patient are independent tumors or a tumor that has spread to another region of the lung, a Mayo Clinic study has found. For patients with multiple tumors, that distinction could mean the difference between early stage cancer that may be cured by surgery and incurable late-stage disease. The research is published this week in the Journal of Clinical Oncology. Dr. Dennis Wigle, the study’s senior author, comments

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