In a postmenopausal woman, ovarian masses are usually a growth of some sort—could be benign, could be cancer, could be something in between called a borderline tumor. Imaging and tumor markers may not be enough to rule out a cancer as cancers and benign tumors can look the same on imaging. And there is a small proportion of ovarian cancers that have a normal CA125 level. Further evaluation in the setting of an ovarian mass and pain is warranted. If you would like to be evaluated at Mayo Clinic, you may make an appointment by calling: 507-284-4137.