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Jul 10, 2012 · Insomnia and depression in Sleep Health

Lets assume that you have “aching’ that is coming from small blood vessel spasm, at least in part. This small blood vessel spasm could be “neurovascular” in origin with a nerve going to a small blood vessel (magnified by the millions of small blood vessels in actuality) that undergoes spasm, thereby limiting blood flow to the tissue (eg, muscle, tendon, other soft tissue, bone….etc) and thereby causing limitation of blood flow to the tissue. Patients with diabetes have “neurovascular causes” of their severe foot pain. One treatment efficacious for the neurovascular pain of diabetes that MIGHT be worthwhile trying is Benfotiamine, a fat soluble derivative of thiamine. Benfotiamine was synthesized in Germany ~60 years ago and has been shown in randomized control trials to treat the very painful peripheral neuropathy of some patients with diabetes and this neurovascular complication. Benfotiamine MIGHT be worthwhile trying at a dose of 300 mg (it comes in 150 mg caps) twice a day for a total daily dose of 600 mg. Benfotiamine as studied by the Germans and so far confirmed in US clinical trials has no known side effect though like even placebos “side effects” have been reported by individual patients. Consider identifying a reputable source and consider a trial of this over the counter agent. It works by facilitating the movement of thiamine into the inside of the cell (lining blood vessels and neurons). Inside the cell it is converted into a “cofactor” of an enzyme called Transketolase. Transketolase acts (via use of its cofactors thiamine pyrophosphate and magnesium) to shunt otherwise destructive glucose metabolites into productive versus non-productive pathways. So, a “non-productive pathway” could be: glucose metabolite –> oxidtive stress –> endothelial dysfunction –> microvascular dysfunction –> regional blood flow abnormality (eg restriction of blood flow to a muscle or group of muslces) –> “downstream pathologies” as diabetic painful peripheral neuropathy, severe unexplained muscle cramps, restless legs, gastroparesis, some forms of sleep apnea, kidney dysfunction, retinopathy, microvascular angina (especially in women as per Mayo Clinic Journal review article). Look up “Benfotiamine” in pubmed for more info on the latest possible therapeutic possibilities of Benfotiamine. By the way Benfotiamine does not in humans cross the blood brain barrier – another thiamine derivative synthesized in Japan, Allithiamine – Allicin + Thiamine found naturally in garlic does cross the blood brain barrier. Some individuals with unknown causes of pain can benefit by taking Benfotiamine that does negate the “non-productive pathway” above. Worth a potential “self-trial” after you do a thorough analysis of pubmed articles on Benfotiamine.

Jul 9, 2012 · Insomnia and depression in Sleep Health

Acupuncture might work in some by stimulating the release of nerve endings on small blood vessels of a chemical that causes the small blood vessels to dilate and thereby deliver more blood to the tissue, eg, muscle, thereby relieving some muscle aches caused by spasm of the small blood vessels. Aerobic exercise might help do the same thing by “stressing” the tissues for lack of oxygen, thereby causing the release of natural substances (eg heat shock proteins) by the body that positively affect blood flow in small blood vessels. This results in a pre-conditoning of the body to a tendency for the small blood vessels to “clamp down” as the result of physical and mental stressors. On the other hand depression enhances the body’s tendency to have small blood vessels spasm and thereby cause not so nice “downsream effects”.

Jul 9, 2012 · Insomnia and depression in Sleep Health

For “tiredness’ consider CoQ10 100 mg after a meal containing black pepper that contains a chemical, piperine, that helps with with the absorption of CoQ10. Also piperine is a non-specific monoamine oxiase inhibitor that has anti-depressant activity itself. BUT do not load yourself up with piperine in its over-the-counter very potent form. Then you might have interactions with medications, over the counters and alcohol that could greatly increase your blood pressure. It is hard to “overdose” on black pepper, except as pertains to your tummy. CoQ10 is a natural substance used by the body to generate energy in mitochondria. Sometimes “aches” might originate in small blood vessels more likely to spasm if depleted in CoQ10. Black pepper in a meal before taking CoQ10 can increase absorption into the body of the CoQ10 by about 130%. You thereby get more for your money.

Jul 9, 2012 · Insomnia and depression in Sleep Health

OR ask your doctor about mirtazepine as an anti-depressant and pro-sleep med. AND ask yourself whether you like Rooibos tea to calm your nerves without sedating you. Recommend Celestial Seasonings Rooibos tea: Madagascar Vanilla Rooibos Tea. Rooibos = Africaner for Red Bush. The Red Bush grows in the semi-arid areas of S. Africa where man might have originated. Rooibos tea used by some South African doctors to mellow out after a stressful day wtthout sedation. Has no caffeine. Pretty reddish-brown color with vanilla, naturally sweet taste. If need additional sweetness use Stevia as natural sweetner vs sugar that might “activate you” like the rays of some TV sets that should not be glanced upon for at least two hours before going to bed.

Jul 9, 2012 · Insomnia and depression in Sleep Health

Try exercising between 8 am and 10 am AND between 2 pm and 4 pm OUTDOORS. Couple that with melatonin 5 mg and magnesium with zinc ~400 mg magnesium and `25 mg of zinc one hour before bedtime to reset your clock. Go to bed at a set time, eg, 10 pm.

Jul 9, 2012 · IBS in Digestive Health

Enteric coated peppermint oil. Good for bowel spasms in some. Take one capsule twice a day