I was diagnosed with HS last year, and I have tried multiple remedies, antibiotics, and creams for relief. I only have HS in one area, and it is on my groin. It is the most painful thing that I have ever experienced and I would not wish it on my worst enemy. I have tried Keflex, Minocycline, and now they have me on Doxicycline. I also tried various vitamins, tea tree oil, hot presses, epson salt, various creams and ointments, etc. I had a follow up appointment with my dermatologist last week, and he prescribed me to a steroid cream called Vanos. We had tried steroid creams before, as I had used Halog to try to get some relief. My dermatologist said that he had never used Vanos on someone with my condition, but it was worth a shot if I was willing to try it. (of course I was.) Well, I used it for the first time last Thursday night. Of course, with something like this, it is frustrating to not see improvement immediately. But, come Sunday morning, half of my knots were flat, and I have continued to see improvement since. Here it is Wednesday afternoon, and I rode my bicycle yesterday completely pain free.:) 90% of my knots are flat, and I do not hurt at all. If you would like to try this, I will tell you what all I do on a daily basis: I take 300mg of Doxicycline (100mg 3x daily), I wash in the shower with Hibiclens Antimicrobial wash (you can get this at drug stores, it comes in an aqua colored bottle), throughout the day, I will use an antimicrobial foam soap to clean myself, it is called H2Ocean, and you can purchase it at tattoo parlors, it is generally for tattoos, but can be used for first aid purposes, and I apply the Vanos generously to the area at least 3x daily. In under a week I have had drastic improvement. Best of luck to you. I will be praying for you, as I know this is extremely difficult to deal with.