I have had CLL for over 6 years. Watch and wait is a common way to address this. My doctor told me some people never need treatment.In my case my white cell count kept going up to where I did need treatment. In 4 years my count exceeded 200 thousand and lymph nodes in my neck and under my arms were swollen. My spleen was also enlarged. At this time treatment had to start. I got into a clinical trial in which rituximab was given to me in by IV in I think 1 treatment a week for a month then I treatment a month for a couple of months. All that while and to this day I take I take 3 140mg tablets of Ibrutinib daily. My white cell count is down to 12 thousand, lymph nodes are no longer swollen and there have been no side effects. There was a group of people in the trial who only took Ibrutinib and I understand they are doing well. A negative about Ibrutinib is that it lowers your immune system.My immunoglobulin numbers are low. I have not had any problems related to this. I hope this helps you.