I was diagnosed with MAC and bronchiectasis 15 years ago. I was on the "Big 3" for 18 months at that time. About 10 years ago I had a positive sputum culture, again, for MAC. Because I was pretty much symptom free with O.K. pulmonary function tests and CT scans, the physicians at Mayo Clinic decided not to treat. Fast forward to today…I am now having some symptoms (weight loss, increase respiratory illnesses, chest tightness). The MAC is still there (along with a few other lovely bugs!) so we have decided to treat it again. Back on the "Big 3" starting next week. Although it isn't pleasant, I've gotten through it before, so I'll do it again! Good luck to you.