Hi Trivia. Colleen also tagged me on your post. I'm sorry but I can't be much help when it comes to liver lesions. My metastatic cancer is to the femur, humerus, lungs and skin. I'm on my 14th cycle of Ibrance with Letrozole for IDC. I've had good results so far, with CT Scans done every 3-5 months. My lung mass shrank a great deal, bones are stable or better, skin lumps cleared up right away and breast mass wasn't even mentioned on last Scan. Side effects seem to be my enemy mainly. I never had nausea with Ibrance but after 8 – 10 months started hair thinning, aches in my joints and pain in my rt. heel, eyes watering. I'll take those over progression. I hope you see some good results with this but as my Onc told me "you must be patient, you won't see immediate results". I'm not going anywhere.