I've just noticed this post so forgive me if this solution has already been suggested.Prior to my transplant my itching was so bad that i drew blood on the front of my legs; I still have the scars. I tried everything my doctor suggested but nothing worked. i saw E45 anti -itch cream and decided to give it a try. It worked beautifully and I had relief at last. My doctor gaveme huge bottles of the stuff and I used it every day until my transplant and for a while afterwards. I still always have a tube in my drawer for emergencies. i know it doesn't work for everyone but it worked for me so it's worth a try for anyone suffering the horrors of itching.