@windwalker I have been on the Big 3 for 7 months and tolerating well…ONLY because I am taking a good probiotic the night before. My history with antibiotics has shown that I not only become constipated but I don't sleep well and as a result am out of sorts. All fine with the probiotic. We are not only killing off the bad bacteria but the good as well, so replenish your colon with plenty of good! Take at least 12 hours before the antibiotics. ALSO! I have Medicare Humana Choice PPO here in Florida. Found that I could reduce the my co-payment cost of Ethambutol and Azithromycin by having a tier exception request form sent to my Infectious Disease doc who prescribed them. He signed and sent to Humana resulting in a change from Tier 3 drug to Tier 1 copay. Big Savings!