My daughter researched it and knows more about it than I do. I haven't gotten to Colorado to speak with a doctor about it – I will be there after April lst. I'll let you know more after I talk to my daughter and get all of the details. She did say you have to be off anti-depressants when you take these mushrooms. After I see a doctor and get approved – I do know you have to go to certains doctors to get their approval. I would like to hear from some of you that have tried it and see if it really works better than anti-depressants and anti anxiety drugs. Anyone out there that have tried it?