I've was on Prilosec for 20 years. (since it available by prescription only in 1998). I had a hiatal hernia, h pylori and scaring in my esophagus. I made a conscious effort to try to come off the medication after reading some disturbing reports. It was rough for the first week or two but I can say that after a couple weeks I have absolutely no GERD symptoms whatsoever. It was as though I became dependent on the medication and when I missed a single dose the acid re-flux I experienced made me go back to taking the medication. I should have quit taking it years ago.