My mom is 65 and has battled depression for a long time. Zoloft worked well for a while until it didnt. Then she went through a whole host of medicines, including effexor and cymbalta and abilify and neurontin and others i cant remember. She developed really bad, Parkinson Esque tremmors. She went in patient at a hospital and was safely weened off of the various meds. Then she tried remeron and that made her zombie ish. Now she's back on Zoloft. Dr says sometimes if you take a break from zoloft and go back to it, it works well. She's on day 4 of 150mg and her mood has not changed one bit. She still has the crying fits and that internal shaking feeling off and on but not every day. I know it's early but i'm praying constantly that this does the trick. I'm worried about adding more meds to the zoloft regimen, or switching meds.