Thank you so much for your help. Since my ET & jak2 positive diagnosis and told to google my disease I feel somewhat bewildered. My first ear surgery was in 2016 for a perforated ear drum (cause unknown) it was a Tympanoplasty. Shortly after, about 2 weeks I started getting infections which would go from viral to bacterial. Treatment was always ofloxacin. The ENT at that time told me after 6 months that there was nothing more he could do and would refill my script as needed. When I moved to Missouri, the infections were still going on every couple of months. I found a great ENT who treated me for about 5 months and decided surgery was the only solution. He did a total reconstruction, removing the mastoid bone and creating an ear drum. I felt so good. No pain, I could hear some and was starting to heal and the infections started again. First viral then bacterial. He hadded Ciprofloxicin-hydrocortisone to my drug regime and recently put me on Fluconazole Tablets. The drug Hydroxyurea 500 mg has my system so messed up I don't know where to turn next.