Plaquenil is a DMARD. The biologics, I believe, are the ones that are concerning for lymphoma. I think DMARDs actually slow down the chance of lymphoma. But yes, I hate the idea of taking drugs for a disease that I don't feel I have. I asked my rheumatologist what the repercussions of not taking a DMARD now were and she said they were "significant." The purpose of the DMARD is to prevent damage to joints and the progression of the disease. So, she wants me to start before I start having symptoms. It's just a hard pill to swallow, so to speak.