Hi @karina77 Thanks for trying to help someone with CFS. It is often misunderstood by many. I chose not to go the Mayo route since their website isn't even up to date on CFS — continue to recommend cognitive behavior therapy and graded exercise therapy which in 2017 were proven inneffective or can even worsen the disease. According to the CDC it is a physical, multisystem illness. I have been on a lot of online support groups and have not come across anyone who said that Mayo was helpful with CFS. Some sufferers were even declined an appointment. I really dont want to sound all negative! Many have found improvement by working with functional or naturopathic doctors. If this person has other ongoing issues, maybe Mayo can help. We are all unique. I wish this person healing soon!