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Dec 9, 2018 · Can a person take Forteo again after a 5 year break? in Bones, Joints & Muscles

to cvillegal- If you read the package insert for Forteo, I think you will find that the FDA recommendation is for Forteo to be limited to 2 years total for lifetime. It is due to a cancer risk. Good luck

Nov 29, 2018 · Osteoporosis in Bones, Joints & Muscles

Your question mentioned that some meds do not help you build bone. That used to be true– until a few years ago, the meds, bisphosphonates and others, slowed the bone turnover. But newer ones that work like a hormone we have, PTH, have resulted in stronger bones. These types of meds have to be injected– Forteo and Tymlos. Many people on this chatgroup have had bad experiences with meds, but people can have different reactions. I took Fosamax for 5 years without any bad effects. My bone density stabilized then even went up a bit. But when density started down again, my doctor (an endocrinologist) recommended Tymlos, because it has been shown to increase density in the spine. I wanted to build on what I have, not wait until I lose more. I walk on a treadmill for an hour every day and usually lift weights 2-3 times a week– and have for 8 years, and try to get my calcium from diet, but with exercise and calcium and Vit D I still developed osteoporosis in my spine. I did not like the idea of self injecting but I tried it, and have been on Tymlos for over 6 months, with no side effects after the first week or so as I was getting used to it. Until I have a follow up bone scan, I will not know if it is increasing my density or not. But from this one person's experience, I can say that not everyone will have muscle pain etc. I understand people not wanting to use meds, but for me the natural process of bone loss in the spine is something I wanted to avoid if I could. People's bodies are different, and risks are different. Good luck with whatever decision you make. Exercise is certainly helpful.

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

Hello, I have been using Tymlos for 4 months. I had never used an injectable, but after the first week, I became much more comfortable with it. I got training from a nurse at my clinic's office; she deals with diabetics and other people who do injections, so she gave me tips. It is good to see the trainer in person, because your body type may affect suggestions on the best ways to inject. I had read, as is often the case online, of people who had experienced dizziness, etc. Accordingly, I give my injection at night, and lying down, I remain lying down for a few minutes to avoid any dizziness. I also do not take calcium before the injection, because a few times I had a bit of headache found I did not if I had not used calcium before the shot. I don't know that there was any relation, but just decided to not use calcium before the shot. Also, I saw in one report that the drug is more effective when given in the morning, and plan to ask my endocrinologist at my next appointment. Anyway, I have not found the shots or the possible effects to be what I feared.
I found the hardest thing is to keep the location of the injections well-separated. You are supposed to stay at least an inch away from the vertical middle of you stomach, and away from the most recent injection sites.
I had taken Fosamax for a few years; it had some beneficial effect on bone density, but recent scans showed I have continuing loss of bone density in my spine. I have a well-informed physician, and from what I read Tymlos has a beneficial effect on the spine. For my insurance coverage, prior trial of a Fosamax or other such treatment was one of the criteria for prior authorization.
Hope it works for you.

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

I hope that Tymlos works for you and me. Tymlos, (and Forteo– similar but has to be refrigerated and costs more) are the drugs that have been shown to build bone, not just slow the loss. As my doctor suggested, it is better to increase your bone bank as early as you can. Sorry to hear that you have a broken vertebrae– the silver lining there is that a non-traumatic break is also satisfies the criteria for insurance coverage. You do not start the medication until you have training. They do have a phone option for training, but my suggestion was for in person, so that the trainer sees your body proportions.

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

I just saw this brief description on a follow-up study on Tymlos mentioned in an investor report–"Patients who completed 18 months of Tymlos injection or placebo in the ACTIVE trial were transitioned to receive 24 additional months of open-label alendronate, a bisphosphonate.

Bone Mineral Density ("BMD") was measured at the lumbar spine, total hip, and femoral neck from the beginning of ACTIVE to the end of ACTIVExtend. Results showed that BMD response rates increased in both the abaloparatide followed by alendronate group and the placebo followed by alendronate group from ACTIVE baseline through the 43 months of ACTIVExtend. Additionally, greater BMD response rates of more than 0%, 3% and 6% were noted in the abaloparatide followed by alendronate group versus the placebo followed by alendronate group at all three sites combined at 43 months. At each anatomic site, BMD increases of more than 3% and 6% were noted respectively at each visit and at 43 months.

60.7% of abaloparatide followed by alendronate patients experienced BMD increases of more than 3 % at all three sites as compared with 24% of patients who received placebo followed by alendronate. The results from the ACTIVExtend Responder Analysis are consistent with the significant BMD response with Tymlos versus placebo observed in ACTIVE trial."

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

My understanding is that both Forteo and Tymlos, after being taken for the allowed 2 years, are usually followed by some one of the bone maintenance drugs, such a bisphosphonate, to maintain the bone gain.
BTW, You asked about side effects. Eight weeks after I started, my doctored ordered tests for calcium, creatine, and PTH to assess whether the injections might be having an adverse effect; those tests were for me all normal. PTH- parathyroid hormone (often described as a sort of calcium thermostat) when elevated can cause your body to think that you do not have enough calcium resulting in calcium being pulled from bones– so blood or urine will show excess calcium. Forteo and Tymlos are some type of parathyroid, but if they work as intended, strengthen rather than weaken bones. You might notice a sense of rapid heart rate when you first do the injection, but it goes away quickly; I had it a few times during the first two weeks. Not at all a big deal to me, because I had read that PTH increases heart rate & figured it was just my body acclimating. As I said, I was anxious at the start, but have found that the self injections and the drug were not such a big deal. I sure hope it works to strengthen our spines.

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

I give my injection at night, seems easier than as part of a morning rush. And my bedtime is more consistent. But for Forteo, which is similar to Tymlos, this study showed a significantly greater response in the lumbar spine when injections were in the morning. Has anyone heard more about this?
"A 12-month morning teriparatide (TPTD) administration resulted in a larger increase in the lumbar spine bone mineral density (BMD) than the evening application. The results indicate that the response of bone cells to teriparatide treatment depends on dosing time." "After 12 months, the lumbar spine BMD grew markedly (p 

Oct 21, 2018 · Forteo vs. Tymlos in Bones, Joints & Muscles

I replied on another thread. More information– even once you receive insurance approval. To use the drug, you will need to have a training session. I think an in person one is good because the trainer can see your body type, and give you tips accordingly.