Hi @baby99 Caner does suck. I was diagnosed with BC in June 2016, and MBC in the bones in September 2017. I was on Ibrance from 18 months. I did great on it. No major side effects. I just went off of it because I had more spread. But it gave me 18months of feeling good and keeping up with my 3 year old daughter. I have also tried Marijuana off and on for pain and stress. I don't have the GI issues you mention above, but it did work great for stress relief. . I do have a lot of pain though-tout on body so i take percocet everyday, and it works great for me. Best of luck on figuring it all out and what the right make of of drugs are for you.