@lindaeb13 thank you. I've been only on Trintellix now for a few weeks. I still have my ups and downs though. I started on 5mg Trintellix and now am at 10mg Trintellix daily. The transition was horrible to say the least, but I've had a lot going on with my life. I broke up with an emotionally abusive boyfriend, lost my job and things are crashing down around me it seems, but I've been able to keep it together. Not sure if I could without any medication. Good luck with your transition. I had that flat feeling while on Celexa. I still get headaches, but not sure what they're from. I would never recommend Effexor to anyone just due to the effects of going off of them. Have a great day!