From what I’ve seen I don’t think 250 mg once a day will do it. It MIGHT (because everybody’s different) , but I doubt it. I would at least do 500 mg twice a day and see how the next PEth looks.
Very hard to say when it will kick in. I imagine it will start working against PLD right away…but in terms of when it will work OPTIMALLY, we might assume that that will require the drug to reach a “steady state.” We really don’t know about Honokiol to address these issues, but there are some GENERAL rules we can apply.
In rats, doses of Honokiol given IV (rather than by mouth) have a half-life of about an hour. But it’s hard to apply that to our situation because we’re requiring absorption from the bowel rather than direction injection into the blood. Plus Honokiol is primarily metabolized in the liver, and that can complicate things when you’re dealing with an oral drug.
An educated guess is that you’d be a steady state in five to 10 hours. That’s just an educated guess.
Another, maybe less reliable rule of thumb is that you’ll steady state after seven doses of the drug. Whatever the car, it’ll start working quickly.
All of this info just highlights the overarching point that these mendacious, unethical test developers are really putting a lot of people on the spot by trotting out a test without sufficient study. How they can look at themselves in the mirror every morning is beyond me. And, no, that’s a comment on their lack of ethics, not their lack of looks…though….I’ve done some. background on these punk test developers and seen photos of some of them. Shhhh…just between you, me, and the wall….the mug on each one of them would make a freight train take a dirt road on a GOOD day. But shhhh on that.
I dang wish a good lawyer would get on this issue and take these for-profit test developers and companies to school. In Federal court!