I see my general practitioner tomorrow. The doctor that prescribed it said he had never heard of this kind of reaction and the ER doctor was totally in the dark. The prescribing doctor said it must be working since the inflammation was in each of the joints. This morning my right foot was so swollen that all of my toes were pointing straight up. The pain is almost to the point of being unbearable. And yes, thoughts of just ending it have gone through my head but the repercussions of that keep me from doing it. I don't want anyone to have to clean up the mess!