I used Zofran with good results for 10yrs, which included use of Phenergan. My condition is gastroparesis. Finally, the nausea was so severe that I just didn't get off the couch. I would ask if there was anything else for nausea treatment and I was told no. I did some internet research and started coming across articles talking about the use of Marinol which has been around since the 80s (synthetic THC). I asked my gastro if I could try it and even though I'm still dealing with nausea it has given me the ability to get up again.