My boyfriend begins a nivo-ipi trial tomorrow after first line chemo/radiation did not work. Originally diagnosed with Stage 3 NSCLC, shortly after ending first line treatment, bone pain led to a PET which showed metastatic NCSLC. It was likely Stage 4 all along, but was to micro to detect. He is really struggling with breathing, energy, appetite, etc. How long before we know if this treatment is showing positive results?