@lindak1tx welcome to our group. As others have replied, I will report my experience with depression. There are 2 main reasons for depression. One is experience, that is what have we and/or are now going through that causes us stress. Are we dealing with it a good way. That is where a therapist comes in. I have gotten a psychiatrist, but nowadays in the U.S. that is hard to get. After being with him for a year, he is turning me over to a nurse practitioner. That is the way things are going so I realize I need to accept it and go on to using that to my advantage. I also had depression most of my life. That brings up the second cause of depression, a chemical imbalance due to my brain not properly handling the chemicals that control moods. That is where the antidessants come in. Like you, I became resistant to them. Mayo has done some research and concluded that it is a result of no longer having enough of the medicine. As we age our bodies become less efficient at digesting it. Also we may gain weight. Thus we need more. I am taking about 3 times the normal dose and it is finally working. I have been mostly free of depression for over a year. I realize I still need to deal with how I handle life's situations so I work on that as well. I need to make sure to eat properly, get enough sleep, and not be negative in my thinking. I hope this helps you and please keep me posted on how you are doing.