@anniepie Hi Annie. I have been on the Big 3 three times, but try as I might, my body could not tolerate them. Azithromycin is actually the only drug I could tolerate for any length of time without serious side effects except for hearing loss and tinnitus which have improved now. The ID doctor would not allow me to drive because of the color blindness that can develop from one of the other two, but not many ID doctors feel that way. MAC has been very debilitating for me due to other “comorbid” conditions. It is very important Annie to eat nutritious meals,exercise, and practice mindfulness as much as possible although that is easier said than done. This site has wonderfully caring, kind, and intelligent people who have a willingness to walk with you through this journey. So glad you found this group.