What's in a gene?

A quick Google on these indicates that the SPOP mutation is extremely common in most prostate cancers.
However, the ASXL1 mutation is most commonly associated with blood disorders. Do you have any history of this or current bloodwork indicating s possible problem?

https://www.targetedonc.com/view/tp53-rb1-pten-mutations-linked-to-worse-survival-in-prostate-cancer#:~:text=TP53,-%2C%20RB1%2C%20PTEN%20Mutations
You may also want to read this. It suggests treating your form of cancer, more aggressively, using both a testosterone blocker (ADT) and an androgen pathway receptor blocker.
Phil

Thanks for the reply. I did the google thing before I posted and found what you found. I was hoping someone might chime in who may have had one or the other and could provide information on longer term treatment once ADT/ARSI becomes ineffective. Due to the TP53 mut, Pluvicto is not going to be a next step in my case. Seems to be multiple studies of the other 2 with little info on treatment options/outcomes from what I could find. I saw that the ASXL1 mut is mostly associated with leukemia. Hopefully, with all the poking and prodding, they would have found that by now if I had it. My bloodwork has come back generally normal. Thanks again!

Yep, already on them. (Orgovyx & Nubeqa) I'm 2 months into treatment with radiation coming up in October. Doc says I'm a weirdo and he's already looking for any trials addressing it. Just taking a shot in the dark to see if there are any other similar weirdos on the board. Thanks, Phil.

Mike