What time of day to take Tymlos

That study is actually about Forteo, but Tymlos is a similar drug so maybe the conclusion is still valid?

I think one reason some people take it at night is that they're better able to deal with the side effects. I take it in the morning.

Unexpectedly I had fewer side effects after switching to morning. I read that study on the relative effectiveness of Forteo in the morning, after I switched!

Interesting that P1NP was higher in the evening group, while DEXA was higher in the morning group. I wonder what the REMS results would have been. I think REMS as an ultrasound is more accurate than DEXA an xray. Arthritis and fractures can contaminate DEXA results.

When you switched, did you inject at night and then the next morning to get on a morning schedule or did you skip a day?

Thank you so much for sharing this! If accurate, it is really statistically profound and I wonder why this is not in any of the TYMLOS or other literature or shared more widely. As someone who has no side effects, I could take the injection anytime and mornings are actually more convenient than carrying the pen and a needle and leaving dinners, movies and other events out to inject in a restroom somewhere.

@esb13 Tymlos is short acting so it probably doesn't matter if we do it the next morning. Skipping a day has no negative effect either, since Tymlos doesn't build in your system. Your call!

With most drugs, if I change timing, I do it gradually, so, say, 8 pm then 4pm then noon then 8 am. I don't remember if I did that with Tymlos but if I did it was unnecessary 🙂

You can ask the distributing pharmacist if you want to but I didn't!

There might be a very simple explanation for the PINP results. If we assume that the injections were either at 9 AM or 9 PM but blood draws were at 8 AM, Then the time between injection and blood draw would be 23 hours for the morning group but only 11 hours for the evening group. Since PINP does not remain constant throughout the day, this may partially explain that result.

I began injecting Tymlos in the morning, but because that’s when I exercise, I decided to inject at bed time. My heart rate would increase a bit and with exercise, even more so, so injecting at night alleviated the noticeable side effects.