Use of Herceptin for clear cell endrometrial cancer Stage IV

Posted by kbearmi @kbearmi, Feb 4 10:15pm

Have Stage IV clear cell endrimetrial cancer. Surgery on August 31, 2025 removed all visible cancer. Several lymph nodes involved. Carbo/pacil with Avastin not working. Cancer has returned. They're considering using Herceptin.

Has anyone take this? What was/is your experience with this?

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

Denise | @denisestlouie | Feb 5 6:30am

I've had herceptin throughout my chemotherapy and it's what I'm receiving as maintenance. The side effects on a day to day based are minimal. It's not chemotherapy it's a targeted drug. The worse potential side effect is heart toxicity. I am working with a cardiologist to oversee what's going on with my heart.

The drug is showing promise in lengthening life span for woman with rare uterine cancers.

I had no quorms with this drug being prescribed for me.

kbearmi | @kbearmi | Feb 5 8:11am

Thank you, Denise. That is helpful.

Helen, Volunteer Mentor | @naturegirl5 | Feb 5 8:58am

@kbearmi I typed "herceptin" in the search box at the top of this screen. You might like to try that too. Most of the prior comments and discussions I located were in the Breast Cancer Support Group.

I did find a Discussion in which the members discuss herceptin in combination with other medications. @rainna has been on herceptin and she may have some helpful information for you.

Here is the Discussion:

Anyone Living with Metastatic Endometrial Cancer:

-- https://connect.mayoclinic.org/discussion/anyone-living-with-metastatic-endometrial-cancer/?pg=1#comment-662663

kbearmi | @kbearmi | Feb 5 9:41am

In reply to @naturegirl5 "@kbearmi I typed "herceptin" in the search box at the top of this screen. You might..." + (show)

Thank you!

cookercooker | @cookercooker | Feb 5 11:44am

In reply to @kbearmi "Thank you!" + (show)

Hi there,
thought I'd chime in. I have IIIC1 (maybe 2, now) serous cell uterine cancer. Was diagnosed in June 2023. Underwent Carbo/pacil --6 rounds. Cancer metastasized in to pelvic and para-aorta lymph nodes. Had one month of Letrozole (hormone therapy drug), to see if it might shrink tumor. It didn't do a thing. Went off of that, and after a multitude of CT scans, and PET and MRI scans, the cancer showed it had spread and original lesion had grown. All this to say that the Carbo/pacil didn't work for me, in my case, hormonal therapy was a waste of precious time. I'm what you'd call, platinum-resistant. The doctor didn't say this to me; I looked it up, as with almost everything else. AS for Letrozole, it has only a 9% efficacy rate.
I have had no other systemic treatment since then. Just had a short, one-time burst of radiation to relieve pain and bleeding coming from a new, substantially large lesion in pelvis. Hasn't done anything. Now I'm waiting for participate in a clinical study using Enhertu, a targeted treatment using trastuzumab + deruxtecan (T-DXd). Trastuzumab is the clinical name for Herceptin.
All this to say that Herceptin is being used with other chemo drugs, in my case, deruxtecan, which have prove to be successful in extending PFS and OS for cancer patients with HER2 positive IHC3+, especially, and IHC2+ moderately. I am IHC2+.
Fingers crossed.
You might consider inquiring about the T-DXd for yourself.
Best of luck and know that you're not alone in all this.