Tymlos results: good!

That's awesome, congratulations! I did 4.5 months of Tymlos last year and am hoping it's done some good.

I should add that my bone markers were never particularly exciting, My P1NP, for example, was around 60 after six months on Tymlos. The bone markers don't always tell the full story.

Hi @njx58 congratulations on your great results! I agree with the notion that bone markers don't always tell the whole story; however they can be used as an imperfect tool nonetheless since there are few available to us at present. Did you by chance get btms checked at 1-3 mo after initiating tymols? It seems bone marker change peaks between 1-3 mo for tymlos according to studies. What were you baseline CTX and P1NP if you don't mind sharing? Thanks.

Yes, my doctor had me repeat tests:

Start: P1NP 36, CTX 305
Five months: P1NP 58, CTX 188
Eight months: P1NP 54, CTX 165
Today: still waiting for results

So my P1NP never really got that high. My CTX dived, so I guess the ratio of the two was improving, My vitamin D was below normal at 27 at the five-month mark, but I've raised it to 45.

Now... I don't know if biology plays a role. I'm a 66-year-old man who is 5-11 and active, including running and resistance training. Does that impact the markers? No idea.

Thank you very much for sharing your treatment experiences with tymlos. Your P1Np didnt change "much", but increased greater than 10 mcg/L which was considered as a therapy target in some clinical studies. CTX reduction, which could occur with tymlos although not common, definitely helped. It's very interesting how each individual's bone markers act differently to pth analogs. Thanks again.

Yay to you njx58!! ! Congrats and thank you for sharing. Can you share what resistance training you are doing? I have always been active but am now hyper focused on specific OP exercises. I am in a 2day/wk resistance training program for OP and eager to learn what your program is. I am proud to say, after 5 months, I am now up to 2 sets of 5 military pushups (couldn't even lift myself up in August) with the goal to get to 2 sets of 12; farmer carries (up to 20lb) single arm for 3 sets of 1 min ea; and lastly 3 sets ea of various pulley machine exercises. I also use a treadmill (walking) for 2-4 miles/day. My P1Np also did not rise much; 82 at start to 94 at 6 months. I will have my DEXA in May, after 1 year on TYMLOS. Mostly I feel so much better mentally as well as physically with this routine that whatever May results are, I know I am in a better place.

I've mentioned that I'm a male who has been going to the gym for a long time, so I might not be a good example for some folks who are new to resistance training. Also, I run, so that's weight-bearing.

That said, I feel pretty much free to do anything at the gym EXCEPT for anything that involves curving or twisting the spine, or bending over and lifting something heavy. Some exercises I do that put reasonable stress on the back:
- Seated pulldown (for back muscles)
- Standing calf raise (lifting more than your body weight on your toes, so weight-bearing)
- Back extension (but start easy)

One reason to work on back muscles is that the stronger your back is, the more it helps support your spine.

Also, if you do a search for "osteoporosis resistance band", you will get a lot of good ideas, and those are exercises you can do at home.