Triple Negative Breast Cancer: What treatments are you having?

The article that I posted above addresses the difference in the pattern of recurrence for triple negative compared to ER+ breast cancer.

"Many triple-negative breast cancers differ significantly from hormone-positive tumors in that they are less likely to recur late, that is, five or more years following diagnosis.

With estrogen-receptor-positive tumors, the incidence of recurrence remains steady for at least 20 years following the diagnosis, even for very small, early-stage tumors. In fact, people who have estrogen-receptor-positive early-stage breast cancer are more likely to have a recurrence after five years than in the first five years following diagnosis.

In women with hormone-positive tumors who are treated with hormonal therapy for five years after surgery and/or radiation/chemotherapy, the distant recurrence rate between year five and year 20 ranges from 14% for small, node-negative tumors (T1N0) to 47% for larger tumors that have spread to lymph nodes (T2N4-9).8

The lower incidence of late recurrence with triple-negative breast cancer wasn’t as clear until recently, as many studies only went out five years when looking at recurrence and survival.

A 2018 study, however, looked at people with triple-negative breast cancer who were disease-free five years after their diagnosis. Among this group, the 10-year recurrence-free rate was 97% and the 15-year recurrence-free rate was 95%."

Sad to hear of your reocurrence and I pray that it will be treated and you will be back to good health again quickly
I worry every day about my triple neg coming back.
Where did it reoccur?
How did you discover it?
What treatment will you have?

Thank you 😊

As I understand it, with triple neg it is a matter of druggable targets and being able to truly get rid of it in the first place. This is the biggest problem that researchers I have met want to solve. I do know for positive there is literally an army of doctors and researchers working on this, and things are getting better all the time. The same is true with the her2, oncotype which is truly an aggressive form because of the way it grows. I would love to read anything that says triple neg is less likely to recur. That would really bring me joy.
How are you feeling with all of your treatments?

I think there's a difference between how aggressive a cancer is and its likelihood of recurrence. The article linked below gives some clarification. As with anything related to breast cancer, treatment options and plans are changing all the time as new tools become available or improved. So keep in mind that any statistics collected over time, say 10 years or so, can include data on earlier patients who had different more-limited treatment options vailable at the time. And might include patients whose cancer was found later than they are now since older women did not routinely have mammograms in the past.

Basically most newly-discovrered breast cancers today have better overall prognosis in general because of advances in treatment options. I like to stress this as it's both true and encouraging when considering 'statistics.'
https://www.verywellhealth.com/triple-negative-breast-cancer-prognosis-4778440

TNBC is most aggressive breast cancer out there. I am dealing with a reoccurrence only after 2 and 1/2 years after my original TNBC.

I was diagnosed with Stage 3b triple negative Invasive Ductal carcinoma with a ki-67 of 95% in April. Started 6 months of chemo in May, then surgery and radiation. Then a year of immunotherapy. I was surprised to read the comment above that there was a high recurrence of triple negative because I read an article recently that there was a lower recurrence in triple negative. Unfortunately I can't remember where the article was from.

I should add that, while 84.6% odds of survival over 5 years for the 'surgery only' option I took are interesting, I also had the OncotypeDX genetic assay and that yielded 95% odds of no locoregional recurrence within 9 years which was more reassuring.

Speaking of algorithms, I entered my DEXA score in the FRAX calculator and, if I lose 10 pounds, my risk of fracture goes up! Take all these things with a grain of salt as you are unique, and not an average, but good results are still welcome.

I entered the data for my situation and the algorithm yielded an 84.6% survival at 5 years for 'surgery only.' Adding 5 years of hormone therapy only changed that number to 84.8%. Which is only an insignificant 0.2% differential. I'm older so that might account for the algorithm result. But I find it interesting as I took the 'surgery only' path.

After doing a bit more research, I discovered a very helpful tool published (and available for public use) on the NHS web site (NHS is the UK's National Health Service - so highly reputable). My career was in software and systems with mathematics, I also reviewed the technical approach notes and believe the tool has been well-designed and is likely pretty solid. It may be somewhat weaker for TNBC because it represents a fairly small proportion of cases, so the data used to confirm the results might not be as solid (there could be some minor bias due to having just a little over 2,000 patients with TNBC for their confirmation data pool). So we shouldn't assume it is perfect. But it is likely fairly good at helping give some useful guidance.

This tool is used by UK doctors and patients to help understand treatment options and their relative benefits. It doesn't necessarily map directly for patients here, especially if they go directly into neo-adjuvant chemo before mastectomy. And not all treatment options are captured in this tool. So none of us should use it without consulting with a qualified cancer team. But it might help a bit to have this insight as we're considering options for treatment.

I also recently switched to a different cancer center (won't get into all of the reasons), but feel this center is far better at providing the kind of individualized and supportive care I need. And when I mentioned having looked at this NHS tool, the surgeon said their breast cancer team often uses it to help gain some clarity into relative benefits of different treatment options, and then to help inform their patients about those options.

Here's the link if you want to look at it. Caveat: It really is best if you are working with your provider to make sure you haven't missed or misunderstood some of the inputs. If you use it knowing you may not have those exactly right, and are willing to look at other possible inputs that might apply to your situation after all of the lab analysis is complete (post-mastectomy), then you can still use it as long as you realize it is giving you a general idea, not something solid/definitive.
https://breast.predict.nhs.uk