Treatment for Prostate Cancer Metastasized to Bones

How long does it usually take for Orgovyx and Erleada (together) to have an effect on psa score?
Is it days, weeks, months?

Thanks for sharing this.
That's definitely a encouraging clinical trial, assuming the results are comparable, which I am unqualified to assess. If I understand correctly, from whatever the starting point was, the mean overall survival rate was 40 months for the standard of care treatment, and increased by over 20% to 52.2 months with the treatment plan undergoing the clinical trial. Yeah!
Also, great news that at 26 mos from this diagnosis you have no (noticeable) progression. That sounds great to me.
Note: I'm not sure if the other study starting point was newly diagnosed bone-metastatic prostate cancer either. I tried to note that in my comments, but I don't know if it came across. Since I am not a researcher in this field, I am really unqualified to make any independent assessment of these articles. When I summarize something, I'm just restating what [I think] I am reading.
With regard to the link you posted, I only got access to the abstract there. Perhaps the article itself is behind a paywall?
In any case, I have no idea what the actual situation is, but I certainly like 52 months better than a lower number for overall survival :-). Thanks for posting this. Since this was a phase 3 trial over 2 years ago and it went well, can I assume this is now a publicly available treatment option?!

I think that's a little harsh, and unnecessarily discouraging for people with newly-diagnosed bone-metastatic prostate cancer. It really depends on the number of metastases, and even then, there's huge benefit from introducing androgen-reception inhibitors like Apalutamide. I'm at 26 months now, with PSA still undetectable (< 0.01) — tested today — and no progression. I had the metastasis in my spine radiated, as well as the primary tumour in my prostate.

The TITAN study for metastatic, castrate-sensitive prostate cancer (using ADT and Apalutamide) did not even reach median overall survival at 52.2 months. Median overall survival with ADT and placebo was still almost 40 months.

Source: https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.6_suppl.11

As I mentioned earlier in the thread, after watching his videos, it seems a little more nuanced:

- for oligometastatic (just a couple of spots), he recommends "zapping" the metastases (radiation); that was in a separate interview in his YouTube channel
- for more widespread metastases, he recommends the triple therapy right from the start

Again, just a layperson, but the plan seems to be to avoid the really harsh therapy for oligometastatic if you can treat each metastasis separately, but if you can't, then try the triple treatment right from the start instead of one thing at a time.

I watched Dr. Eugene Kwan's video at least 5 times..
Does 'curative' mean cure? He says the "IT' treatment is Triple Therapy...Hormone treatment and with Doxataxcel...
I don't get it...If this is the 'Standard' treatment then why aren't all the Urologists doing this...
Very frustrating...Where do we go...? Do we spend all day researching? Is one treatment better than the other.
My Urologist said there were a lot of side effects with the Doxataxcel Chemo treatment...
And, of course, then there are all the Homeopathic treatments and they all want a lot of money...
Not sure where to go, but I believe the Mayo Clinic should know what they are talking about..?

Thanks for your post! I watched this Keon video last night and I will watch it again today and take notes. I have an 3 month appointment with my UCLA urologist surgeon in 2 weeks and I will discuss it with him. If I am not satisfied with his response I will get another opinion
( hopefully here in LA but if need be I will travel to Mayo in Phoenix) I suspect that Dr Kwon and Mayo are the gold standard and my UCLA follows the medical standard to care , which may be the minimal medical standard of care. I was diagnosed 2 years ago, had surgery and 13 months of ADT and Erleada and if stats are any guide, I anticipate the cancer will wake up early 2025 or sooner. I am working on being proactive and hoping for a good result

Here is an article that overviews treatment strategies as well as describes the metastasis to the bones. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000416/# (Baldessari et al, Bone Metastases and Health in Prostate Cancer: From Pathophysiology to Clinical Implications, March 2023).
If I correctly understand this article, the reality it describes is very sobering. The average overall survival rate is less than two years and the treatments increase survival by an average of 10-20%, or 2-5 months. Because bone health is the overall challenge for this stage, both the growth of the cancer and the deterioration of the bone mass (osteoporosis) are challenges, and to some extent they oppose each other--treatments for cancer may increase the fragility of the bones and treatments for bone deterioration may increase the cancer.
In situations like this asking how we are going to spend the remaining months of life is perhaps more important than how we are going to treat the cancer. Your medical team may not be well-equipped to address this issue with you.
If you prefer charts to words, look for the charts in the article. There are several that overview the course of the disease and the impact of available treatments.
While it is always possible that a clinic in Mexico has found strategies for disease management that no one else has or that a different MD will have a better treatment than our current MD, I am aware of no group of survivors who are saying ten years ago the scans identified bone metastases, but now it is no longer a problem for me. If you're in that group, please speak up?!
There is a stage where the biochemical markers identify that metastasis must be occurring but the bone tumors are not really evident yet. It is as this stage that most of the treatment strategies are trying to intervene in ways that extend the time it takes for the bone metastases to emerge.

I tried his email but it reject Any idea on how I can ask him a question

It is Kwon not Kwan on bottom of slide

Any news

also see https://youtu.be/-RVVq0uDAEE

I’m not sure how to answer on here ! Happy belated birthday !😊 Russ turns 62 Dec 30 ! This place is spelled hoxsey clinic lots to read about ! See what u think ! Russ is really thinking about going 🤔