Thyroglobulin antibodies sky-high 3 months after BC radiation

Posted by diamonddog @diamonddog, 11 hours ago

I would not have known anything was wrong with my thyroid except for the fact that I'm currently working with an integrative doctor in addition to my regular cancer care team. He had me take a huge blood panel for everything under the sun, and my thyroglobulin antibodies (TgAb) came back ridiculously high, many times over the normal range.

Now the integrative doctor is making me worried that I have an autoimmune disease, even though I feel great and have never shown any signs. My MO (as usual) isn't responding to my questions yet about these levels and what connection they might have with radiation therapy (I had fifteen rounds including boosts, ending 8/13/25). The radiation oncologist assured me before treatment started that the worst that would happen is "a little sunburn." Sigh.

Has anyone ever suffered thyroid issues following BC radiation? I had my right breast and lymph nodes zapped following lumpectomy.

I just want all of this to be over, even just for a little while I could use a break from the non-stop side effects that I was assured I wouldn't have (face in hands)

Sorry for whining, y'all. Big hugs going out to everybody.

Interested in more discussions like this? Go to the Breast Cancer Support Group.

You are not whining!

Stop whining that you think you are whining! LOL.

Just messing with you.

You are going through some tough times right now and need some reassurance because your MO isn't answering you and it is frustrating and you are frightened, right?

Let me look up what that test means and get back with you; I love medicine.

By the way: when a test comes out REALLY out of site and you feel fine, I think you may want to consider getting the test redone.

Mistakes in diagnosis and medicine are like peanut butter and jelly.

Again....standby....

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Did you have chemo as well as radiation? Which lymph nodes did they zap, location please?

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OK - read several studies related to radiation exposure via Pub-Med in children exposed to radiation; what inadvertent radiation does to some thyroids (when patients are exposed to radiation treatments).

It seems women's/girl's thyroids are more susceptible to an increases in the TgAb as well as autoimmune dysfunctions from radiation.

High TgAb can mean the radiation treatment you had triggered a very strong immune response. It does not always mean you will have a full blown autoimmune disease appear, but you can have just a very high TgAb without ANY outward symptoms.

The three studies I read all confirm that an autoimmune reaction of the thyroid (hence) autoimmune reaction to the thyroid immunoglobulins can occur (hence your high antibody test) in radiation treatment and exposures such as kids in studies at Chernobyl.

Other studies of women with breast cancer show that there ARE more instances of thyroid problems - including raised levels of TgAb, AFTER radiation treatment; if it is chemo plus radiation the incidence is higher, than if it is just radiation; and lower if it is just chemo. The two seem to have an additive effect - increasing chances of thyroid issues with each added therapy.

Hang in there. This raised TgAb should decrease with time, according to the Chernobyl study; so if you get retested a year after cancer treatment the TgAb level should drop - which makes sense, but the effect of radiation goes away very slowly.

If you don't have any OTHER symptoms pointing to your thyroid, at this point, other than the TgAb being high - which is autoimmune in nature, I would not let more stress worrying about this further stress your immune system more.

I know, easy for me to say. Hang in there...worry does not help or solve anything.

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Profile picture for slarson14 @slarson14

You are not whining!

Stop whining that you think you are whining! LOL.

Just messing with you.

You are going through some tough times right now and need some reassurance because your MO isn't answering you and it is frustrating and you are frightened, right?

Let me look up what that test means and get back with you; I love medicine.

By the way: when a test comes out REALLY out of site and you feel fine, I think you may want to consider getting the test redone.

Mistakes in diagnosis and medicine are like peanut butter and jelly.

Again....standby....

Jump to this post

@slarson14

Yes, mistakes happen!
You know your body best.
Rerun that test and see what other tests there are.
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