Anyone have stomach pain while on Enzalutamide (Xtandi)?

This is not a normal issue with Enzalutamide. Even though he is on Enzalutamide And his PSA may show it’s undetectable, Metastasis can occur and cause issues.

If his PSA is undetectable, then a PSMA pet scan may not show anything, But in cases of large Metastasis it does show up.

In this case, a CT scan may be useful to compare previous to current.

Darolutamide Works very much like Enzalutamide, But has fewer side effects. If they can’t find something wrong with scans, then maybe changing the drug will make a difference.

I'm on Apalutamide and get regular digestive pain like the OP's father's situation, but not as severe (just uncomfortable, not unbearable). While it might be from the Apalutamide in my case, I think it's more likely from my spinal compression, which can lead to nerve hypersensitivity. It could also (less likely) be a side-effect of surgery or radiation.

Hi jeff, it turned out to b liver metastasis. Any idea on this

Well, the expert documentation says that if you catch it early and there’s very little spread, you might be able to do surgery. Otherwise your treatment plan is to stop the cancer from growing. Maybe they can use SBRT radiation, The following paragraph discusses that.

“While radiation therapy can be used to treat prostate cancer that has spread to the liver, it is not usually a curative treatment for liver metastases. Radiation can help control the growth of tumors, relieve symptoms, and potentially improve survival when used in combination with other treatments. However, liver metastases are often considered a late stage of the disease, and cure is usually not possible with radiation alone”

That means getting on ADT (or the Estradiol patch) And an ARSI like Zytiga or one of the lutamides.

That’s the only way to control growth and can work for years, It sure worked for me for eight years, though our cases are different.

You need to talk to your doctor about this. Find out how much spread there is what the doctor thinks they can do and what drugs the doctor thinks you should be on. At least you have some information about choices.

In my dad's case cancer has changed its type to neuroendrocine. And there is 10 tiny spots. We been suggested platinum based chemo

Hi Jeff

Don’t know if you can help my dad has had prostate cancer for 19 years and it is now metastasise to the liver. The spots are scattered but it is not neuro endocrine. He has tried lutetium for six cycles which initially it did have a response to in the liver. then we have done four cycles of docetaxel with Little to no response do you know what treatment there is available if any after this? Time is of the essence

Have they tried chemo using docetaxel along with carboplatin. Usually, when docetaxel alone doesn’t work adding carboplatin can make a difference. I’m not a doctor so I cannot tell you specifics about how it would work. I encourage you to talk to your medical oncologist and radiation oncologist about this. Ask if it might make a difference.

From AI

Treatments like Cerspheres, an injected form of radiation, can be used in certain cases, according to a YouTube video. Cerspheres is an option for patients with multiple liver metastases that are not suitable for spot radiation.

Here is that YouTube video link