Anyone have stomach pain while on Enzalutamide (Xtandi)?

Posted by amee @amee, Mar 31 10:00am

My father has stage 4 prostate cancer and on Enzalutamide for past 2 years. He is currently having unbearable pain in his stomach and around the ribs. Does anyone had that issue while on Enzalutamide madication or in general as a side effect of this disease.

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jeff Marchi | @jeffmarc | Mar 31 10:42am

This is not a normal issue with Enzalutamide. Even though he is on Enzalutamide And his PSA may show it’s undetectable, Metastasis can occur and cause issues.

If his PSA is undetectable, then a PSMA pet scan may not show anything, But in cases of large Metastasis it does show up.

In this case, a CT scan may be useful to compare previous to current.

Darolutamide Works very much like Enzalutamide, But has fewer side effects. If they can’t find something wrong with scans, then maybe changing the drug will make a difference.

northoftheborder | @northoftheborder | Mar 31 1:32pm

I'm on Apalutamide and get regular digestive pain like the OP's father's situation, but not as severe (just uncomfortable, not unbearable). While it might be from the Apalutamide in my case, I think it's more likely from my spinal compression, which can lead to nerve hypersensitivity. It could also (less likely) be a side-effect of surgery or radiation.

amee | @amee | 5 days ago

In reply to @jeffmarc "This is not a normal issue with Enzalutamide. Even though he is on Enzalutamide And his..." + (show)

Hi jeff, it turned out to b liver metastasis. Any idea on this

jeff Marchi | @jeffmarc | 5 days ago

In reply to @amee "Hi jeff, it turned out to b liver metastasis. Any idea on this" + (show)

Well, the expert documentation says that if you catch it early and there’s very little spread, you might be able to do surgery. Otherwise your treatment plan is to stop the cancer from growing. Maybe they can use SBRT radiation, The following paragraph discusses that.

“While radiation therapy can be used to treat prostate cancer that has spread to the liver, it is not usually a curative treatment for liver metastases. Radiation can help control the growth of tumors, relieve symptoms, and potentially improve survival when used in combination with other treatments. However, liver metastases are often considered a late stage of the disease, and cure is usually not possible with radiation alone”

That means getting on ADT (or the Estradiol patch) And an ARSI like Zytiga or one of the lutamides.

That’s the only way to control growth and can work for years, It sure worked for me for eight years, though our cases are different.

You need to talk to your doctor about this. Find out how much spread there is what the doctor thinks they can do and what drugs the doctor thinks you should be on. At least you have some information about choices.