Stage 4 PC Longevity: Anyone have prostate cancer more than 10 years?

Lutetium-177 PSMA therapy is based on the notion that Lu-177 can stick to the surface of the cell membranes that make PSMA. Lutathera and Pluvicto, two drugs with lutetium, were the first to get FDA approval. Radiologists can use it if the tumor has spread to other body parts and isn't responding to chemo or hormone therapy.
Radium-223 dichloride, Xofigo, is used to treat advanced prostate cancer metastasizing to the bones. Radium's structure is also similar to that of Calcium, which is the main element in bone tissue. This similarity makes it easier for Ra-223 to get into bone metastases and kill cancer cells. Since there are no cancerous cells in the internal organs, this radioligand is given.
Actinium-225 PSMA therapy is a novel radioligand-based approach to treating cancerous tumors. The medication molecule can bind to the protein in the same way that Lutetium can. It is used in place of Lutathera in cases where the latter medication is ineffective against prostate cancer.

My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.

My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.

My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.

Just curious, how old is your husband & do I understand correctly it was the Pluvicto that failed?

Yes my husband was diagnosed with stage 4 cancer in 2013. (11 years ago) He has been treated at the Seattle Cancer Care Alliance for 11 years. His last treatment program was Pluvicto. Unfortunately this last treatment only lasted 9 months and has now failed. He is on hospice care in home, currently. We have had many good years and now we are on this last journey. I encourage men to seek treatment early

I will be 62 this fall. and I was diagnosed at 52. I had a prosectomy followed with radiation. Then I had 6 rounds of chemo followed by Zytiga and prednisone for almost 4 years. After that stopped working they put me on Xtandi which didn't work too good, it sort of stabilized my PSA though it started rising after 3 months. Then came 13 rounds of Jevtana chemotherapy. Every 3 weeks from May of 22 until February of 23. PSA was stable but it slowly started to rise. I'm now on Pluvicto. I have just completed my 2nd round of 6 at 6 weeks apart. Too soon to tell if is working. During these years my PSA has been between .20 and never above 3.5 during all of these treatments. I'm on xgeva shots for my bone mets on my rib cage, middle spine and on the back of my neck. The 2 on my back were fractures which have healed nicely. Almost no pain. I get Lupron injections every six months. All I can say is that everyone is different. I have a good sense of humor and just go on like nothing has happened. Fatigue is the biggest hurdle and I can deal with that. They told me at the beginning that they were going to throw everything but the kitchen sink at me in the beginning and they weren't kidding. Hope this helps and good luck!