Stage 4 PC Longevity: Anyone have prostate cancer more than 10 years?

My Xtandi not working after a year Jan Now they want chemo for spinal mets

Psa 9.8 up frpm 1.7 year ago Ideas welsome

Colleen
PSA almost undetectable, and testosterone at 7 (lowest reading).
Side effects of therapy:
Hot flushes
Not as strong 30 percent off)
Not really fatigued
Testicles feel softer
Dry skin
Labs really all normal excepting a small drop in rbc and hematocrit
Long term, who knows--worry about cardio and osteo

@jacksgland, your timeline offers hope to many, living with stage 4 is possible.

How are you doing on Relugolix and Xtandi?

My husband was first diagnosed in 2005. After brachytherapy and external beam radiation, the cancer was in remission until 2011. When it recurred, he referred himself to Mayo and has been a patient of Dr Kwon ever since. After various oral meds and spot radiation to the spinal mets, he had chemo with taxotere in 2016. More spot radiation since, along with Lupron and Zytiga. After three years on Zytiga, another recurrence. More spot radiation until the spinal mets became too numerous in the last few months. Both Dr Kwon and the local medical oncologist recommended Lutetium 177/Pluvicto, and the first infusion is on January 17. Because my husband has already had chemo and radiation and oral meds, he was deemed eligible after a PSMA PET showed many spots with receptors for L177 to hit. The plan is for six infusions six weeks apart, the current standard protocol, as long as they are effective. The projected outcome is not a cure, but an extended remission.

What is the projected out come? Did he have to do chemo first How many injections of 177 planned

Bless you

If spot radiation is not advisable, Pluvicto/Lutetium 177 may be appropriate. That is what my husband is about to start for spinal mets after Zytiga/abiraterone stopped working after 3 years.

23, 18, 10 years; Fabulous!!! Keep going Men!!!

whats next when Xtandi stops working on spinal mets

18 years total. Prostatectomy 2006. Recurrence 2016. Lipron/Casodex since. Quality of life issues REQUIRES a positive attitude. Even if you have not been a positive person, remember that people get very good at what they spend their time doing. So practice, practice, practice.

Hope all goes well. I have been Stage 3 for 10 years, cannot get rid of the cancer, but taking Orgovyx since May 2022. No side effects for me. Staying active. Glad to see that 23 years.