Stage 4 PC Longevity: Anyone have prostate cancer more than 10 years?

My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.

My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.

Just curious, how old is your husband & do I understand correctly it was the Pluvicto that failed?

Yes my husband was diagnosed with stage 4 cancer in 2013. (11 years ago) He has been treated at the Seattle Cancer Care Alliance for 11 years. His last treatment program was Pluvicto. Unfortunately this last treatment only lasted 9 months and has now failed. He is on hospice care in home, currently. We have had many good years and now we are on this last journey. I encourage men to seek treatment early

I will be 62 this fall. and I was diagnosed at 52. I had a prosectomy followed with radiation. Then I had 6 rounds of chemo followed by Zytiga and prednisone for almost 4 years. After that stopped working they put me on Xtandi which didn't work too good, it sort of stabilized my PSA though it started rising after 3 months. Then came 13 rounds of Jevtana chemotherapy. Every 3 weeks from May of 22 until February of 23. PSA was stable but it slowly started to rise. I'm now on Pluvicto. I have just completed my 2nd round of 6 at 6 weeks apart. Too soon to tell if is working. During these years my PSA has been between .20 and never above 3.5 during all of these treatments. I'm on xgeva shots for my bone mets on my rib cage, middle spine and on the back of my neck. The 2 on my back were fractures which have healed nicely. Almost no pain. I get Lupron injections every six months. All I can say is that everyone is different. I have a good sense of humor and just go on like nothing has happened. Fatigue is the biggest hurdle and I can deal with that. They told me at the beginning that they were going to throw everything but the kitchen sink at me in the beginning and they weren't kidding. Hope this helps and good luck!

@jacksgland, your timeline offers hope to many, living with stage 4 is possible.

How are you doing on Relugolix and Xtandi?

I am 61 years old. I was diagnosed with metastatic de novo PC July 27 2022. My birthday of all days. Cancer showed up in my bones - spine, ribs, and hips. I had intense pain at first - I could not lay on my back. After an emergency Gall Bladder surgery - I still could not lie on my back. Went back to the ER - had CT and Bone scans which confirmed adenocarcinoma PC. Started Casodex (30 days) and 10 cycles Radiation to spine and 5 to ribs. Pain disappeared and has never come back. PSA started at 32 and quickly dropped to 1.005. A month later I started Darolutamide and Chemo therapy. I had 10 cycles of Docetaxel because my blood was other-worldy and 10+ cycles of chemotherapy has greater overall survival (OS) stats. Because I could handle chemo very well my doctor asked if I wanted to continue - so I did. At the end of my 10th chemo cycle my PSA dropped to 0.238 and continued to slowly drop to undetectable. I am a slow PSA dropper. All Genetic and Genomic testing also came back negative. I have Zometa infusions every month and eat a 60% plant based diet, exercise (bands & walking) and I work every day. My recent Bone scan showed great improvement and several spots are now resolved. My treatment was patterned after the ARSENS trial. It has been 5+ years since the ARSENS trial ended. At this time Overall Survival (OS) and time to Castration Resistance still has not been reached from the ARSENS trial.

Lastly, I do not look at or except the SARS data. The SARS data is based on ADT alone. This is a Chronic Disease - the medical community does not know how long anyone will live with this disease. I expect to live 20+ more years. Lastly, I find rest and peace with my relationship with Jesus.